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The Science

About AVAs

Your palms contain dense networks of arteriovenous anastomoses (AVAs), specialized vascular structures that regulate heat exchange.

  • Scientific Studies

Celcio’s Key Innovation

Celcio utilizes a controlled vacuum environment to prevent vasoconstriction, maintaining AVAs in an open state even under thermal stress.
  • Sustains blood flow to the palms during both cooling and heating
  • Increases the volume of blood reaching the thermal plate
  • Accelerates heat exchange for faster thermal transfer
  • Enhances overall efficiency of both cooling and heating processes

Applies a principle used in advanced medical and performance technologies, optimized through targeted vacuum control.

Scientific Studies:

  • Effect of heating and cooling combination therapy on patients with chronic low back pain. (Sun Jung Kim, Young Doo Choi
  • Effect of cold & heat Therapies on pain relief in patients with delayed onset muscle soreness. (Yutan Wong)
  • The low-temperature effect on sports regeneration / 2023 (Robert Trybulski, Olha Bas)
  • Blog Ultrahuman: How palm cooling improves physical performance
  • Arterio-venous anastomoses in the human skin and their role in temperature control (Lars Walloe) 
  • Palm Based Cooling Technology for Medical Training and Pain Therapy (Prof. Rudolf Likar)
  • Enhancing Thermal Exchange in Human and Practical Application (Prof. Craig Heller, Dennis Grahn)
  • Cryotherapy and thermo-therapy in the management of osteoarthritis and rheumatoid arthritis. (Yao, Xie, Opoku, Li,)
  • Cold, heat and hypoxia as a medical tool: the use in a healthy and diseased population. (Hohenauer, Rogan, Clijsen)
  • Microvascular dysfunction in peripheral artery disease: Is Heat Therapy a viable treatment? (Anderson, Pekas, Park)
  • Current Indications and future direction in heat therapy for musculoskeletal pain. (Zanoli, Albarova Corral, Ancona, Hotfiel)
  • The effectiveness of hand cooling at reducing exercise-induced hyperthermia and improving distance race performance in wheelchair and able-bodied athletes. (Victoria Goosey Tolfrey, Craig Boyed)
  • Physiology in Sport: Keeping your hands cool can keep your performance. (Andrew Hamilton)
  • The effects of Palmar Cooling on Power, Strength,and Endurance (Madison Kramer)
  • Effects of alternating heat and cold stimulation using a wearable thermo-device on subjective and objective shoulder stiffness (Sawada, Okawara)
  • Effects of a 4-week Avacen treatment on pain perception in fibromyalgia. (Muehlbauer, Vieira)
  • Heat vs. Cold Therapy: Which is best for Musculoskeletal injuries. (Tim Bertelsmann)
  • Local Application of Therapeutic Heat and Cold (Bampton, )
  • Acute effects of cold, heat and contrast pressure therapy on forearm muscles regeneration in combat sports athletes. (Trybulski, Stanza, Muracki)
  • Effects of a new local cold therapy for post-COVID symptoms. (Schneider, Morgenstern)
  • Validating new limits for human thermoregulation (Robert D. Meade, Katie E. Wagar)
  • Cryotherapy and thermo-therapy in Arthritis Management (Yuming Yao)
  • Hand Cooling induces changes in the kinetics of oxygen uptake (Louis Finiel, Daria Neyroud)
  • Heat loss through the glabrous skin surfaces of heavily insulated, heat-stressed individuals. (Grahn, Heller)
  • Work volume and strength training responses to resistive exercise improve with periodic heat extraction from the palm. (Grahn, Heller)
  • Cryotherapy in rheuma-tologic inflammatory diseases (Guillot)
  • Cooling via one hand improved physical performance in heat-sensitive individuals with multiple sclerosis (Grahn, Heller, Murray)
  • The effects of local cold application on fibromyalgia pain (Naside Yilmaz, Kiyak)
  • Heat extraction through the palm of one hand improves aerobic exercise endurance in a hot environment (Grahn, Cao, Heller)
  • Thermoregulation of human hands in cold environments and its modelling approach. (Zhang, Li, Wu, Song)